|Therapeutic Index||Moderate (1:50)|
Caffeine is a stimulant drug that is also the mostly widely consumed psychoactive substance in the world. It is legal virtually everywhere in the world, and is found naturally in many plants.
Legality and Availability
In the United States, caffeinated drinks such as coffee and soda are regulated as food items, while pure caffeine powder is sold freely and without regulation.
Caffeine is notable because it is likely the only stimulant drug that is unrestricted in virtually every country.
The US Anti-Doping Agency does not restrict caffeine.
The NCAA prohibits caffeine if urine concentrations exceed 15 mcg/mL, or "about five cups of coffee a few hours before the drug test."
The International Olympic Committee prohibits "excessive" caffeine intake.
Type 2 Diabetes
|Overall Addiction Liability||Very low|
|Physical Dependence||Yes (mild)|
Caffeine is considered to have a very low risk of addiction. However, mild physical dependence does develop with continued use. This dependence is considered to be of little concern, as the withdrawal symptoms of caffeine are very mild, usually using the user with a headache and/or a poor mood for a few days after quitting.
Psychological addiction is very rare, and has minimal negative effects on the average user.