Kratom

From Spencer's Drug Wiki
Revision as of 15:13, 31 May 2016 by Spenb (talk | contribs) (Pharmacology)
Jump to: navigation, search
Kratom
Legal Status
US Banned in Indiana
Uncertain legality in LA, TN, VT, WI
Legal in all other states
Canada Legal
EU Legal in UK, France, Netherlands
Legality varies elsewhere in Europe
AU Banned
Drug Information
FDA Status Not FDA Approved
Class Opioid painkiller
Stimulant
Addiction Risk Low to Moderate

Kratom, or Mitragyna speciosa, is a plant native to Southeast Asia.

Kratom is an opioid painkiller, notable because it is possibly the only opioid that most Western nations do not regulate or ban.

Legality and Availability

United States

There is no federal law against kratom, but a handful of states have enacted restrictions.

Indiana is the only state that explicitly bans kratom. However, the plant is in a legal gray area in Louisiana, Tennessee, Vermont, and Wisconsin.[1]

Where no state law exists, kratom is legal.

Canada

Kratom is legal in Canada, and sold in many headshops.

Europe

Kratom is legal and sold in stores in the United Kingdom, France, the Netherlands, and other countries.

It is controlled or banned in Ireland, Finland, Denmark, Romania, and other countries.

Legality is questionable in Germany.[2]

Official Uses

Kratom is not approved for medical use by the FDA and other agencies. It is typically classified as an herbal product.

Unofficial Uses

Kratom is an opioid, and has analgesic effects similar to other opioids such as codeine. The drug also has mild stimulant properties.[3]

Kratom is an effective painkiller and has been reported to ease anxiety.

Pharmacology

The active substances in kratom have not been identified and documented. However, kratom appears to possess an effect profile similar to buprenorphine, indicating that it could be a partial agonist of mu-opioid receptors. It is also possible that kratom could be classified as a weak opioid agonist, similar to codeine, dihydrocodeine, ethylmorphine, and tramadol.

Evidence for the partial agonist hypothesis includes:

  • Hypoventilation is rare
  • No overdose has been conclusively documented, despite widespread use in Southeast Asia
  • Kratom carries a dependence risk substantially lower than other opioids
  • Kratom is often used by recovering opioid addicts to prevent withdrawal without euphoric effects

It should be noted that the evidence above may largely also apply to the weak opioid hypothesis.