|AU||Pharmacy Only (S2)|
Loperamide, sold under the brand name Imodium and others, is an opioid agonist that is sold as an anti-diarrheal agent.
Loperamide crosses the blood-brain barrier in very small amounts, but traditionally these amounts have been considered insignificant. However, new research has concluded that loperamide, in high doses, has the potential for a significant analgesic or even euphoric effect. There are also numerous anecdotal reports of loperamide being effective in preventing withdrawal symptoms in those dependent on opioids.
Use of higher-than-recommended levels of loperamide has been associated with cardiotoxicity. Large doses taken at once can cause arrhythmia and cardiac arrest in some cases, raising serious questions about the safety of recreational loperamide.