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Legal Status
US OTC Unrestricted
AU Pharmacy Only (S2)
Drug Information
FDA Status Drug
Class Opioid
Addiction Risk Addiction-green.png Low

Loperamide, sold under the brand name Imodium and others, is an opioid agonist that is sold as an anti-diarrheal agent.

Loperamide crosses the blood-brain barrier in very small amounts, but traditionally these amounts have been considered insignificant.[1] However, new research has concluded that loperamide, in high doses, has the potential for a significant analgesic or even euphoric effect.[2][3] There are also numerous anecdotal reports of loperamide being effective in preventing withdrawal symptoms in those dependent on opioids.[4]

Use of higher-than-recommended levels of loperamide has been associated with cardiotoxicity.[5][6] Large doses taken at once can cause arrhythmia and cardiac arrest in some cases, raising serious questions about the safety of recreational loperamide.[7][8][9]


  1. https://www.ncbi.nlm.nih.gov/pubmed/7438696
  2. http://www.medscape.com/viewarticle/863538
  3. http://www.webmd.com/mental-health/addiction/news/20160505/addicts-using-diarrhea-drug-imodium-to-get-high
  4. https://drugs-forum.com/forum/showthread.php?t=192031
  5. http://www.fda.gov/Drugs/DrugSafety/ucm504617.htm
  6. http://www.medscape.com/viewarticle/863538
  7. http://www.medscape.com/viewarticle/863232
  8. http://www.hindawi.com/journals/crim/2016/4061980/
  9. http://www.acmt.net/_Library/2016_ASM_Posters/Abstract_78.pdf