Sedative-hypnotic comparison

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Drug Name Brand Names Classification Typical Dose Maximum Dose Onset of Action Half Life Duration of Action Legality
Diphenhydramine Benadryl, Unisom Antihistamine
25 mg - 50 mg Us-flag.png 50 mg
Uk-flag.png 100 mg
45 minutes 12 hours OTC Unrestricted
Au-flag.png Pharmacy Only (S2)
Doxylamine Unisom Antihistamine
12.5 mg - 25 mg Us-flag.png 25 mg
50 mg
30 minutes 9 hours OTC Unrestricted
Au-flag.png Pharmacist Only (S3)
PromethazineNote 1 Phenergan, Phenadoz Antihistamine
Antipsychotic (weak)
12.5 mg - 25 mg 50 mg 16 hours Us-flag.png Rx Only
Uk-flag.png Fr-flag.png OTC

1 Promethazine is not officially approved for sedative-hypnotic use by the FDA.[1] It is, however, approved as a sedative for inpatients.